Original Research

Antifungal and antioxidant properties of medicinal plants used against fungal infections

Tambudzani C. Machaba, Salome Mahlo, Jacobus Eloff
Journal of Medicinal Plants for Economic Development | Vol 8, No 1 | a214 | DOI: https://doi.org/10.4102/jomped.v8i1.214 | © 2024 Tambudzani C. Machaba, Salome Mahlo, Jacobus Eloff | This work is licensed under CC Attribution 4.0
Submitted: 07 July 2023 | Published: 01 March 2024

About the author(s)

Tambudzani C. Machaba, Department of Biodiversity, Science and Agriculture, University of Limpopo, Polokwane, South Africa; and, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa
Salome Mahlo, Department of Biodiversity, Science and Agriculture, University of Limpopo, Polokwane, South Africa
Jacobus Eloff, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa

Abstract

Background: Antioxidants present in plant extracts prevent free radicals from causing chronic diseases in humans.

Aim: The study investigated 12 medicinal plants (Kleinia longiflora DC., Berchemia discolor [Klotzsch] Hemsl., Persea americana Mill., Sansevieria hyacinthoides [L.] Druce, Dichrostachys cinerea [L.] Wright &Arn, Withania somnifera Dunal [Ashgandh], Momordica balsamina L., Lonchocarpus capassa, Pappea capensis, ‘Rhus lancea L. fil’ with ‘Searsia lancea (L.F.) F.A. Barkley’ Peltophorum africanum, Maytenus heterophylla [Eckl. & Zeyh.] Robson) for antioxidant activity using the qualitative and quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

Setting: The plant species were selected from the ethnomedicinal plant database of over 300 medicinal plants used for therapeutic purposes in Limpopo province.

Methods: The plant materials were extracted with solvents of various polarities such as acetone, dichloromethane (DCM), methanol, hexane, and water. The qualitative and quantitative DPPH methods were used to determine the antioxidant activities of plant extracts.

Results: The yellow bands revealed the presence of antioxidant compounds against the purple background on the Thin Layer Chromatography (TLC) plates. Methanol, hexane, and water extracts of L. capassa were the most active radical scavengers in the DPPH assay among the six medicinal plants screened. Plant extracts of P. africanum showed strong antioxidant activity by inhibiting DPPH, compared with the standard ascorbic acid.

Conclusion: The findings indicate that some extracts can be used as an easily accessible source of natural antioxidants.

Contribution: The findings revealed that the plant species investigated displayed noteworthy antioxidant activity, which provides scientific evidence for their utilisation by traditional health practitioners to treat fungal infections.


Keywords

antioxidant activity; antifungal activity; medicinal plants; fungal; inhibitory concentration

JEL Codes

I23: Higher Education • Research Institutions

Sustainable Development Goal

Goal 3: Good health and well-being

Metrics

Total abstract views: 291
Total article views: 285


Crossref Citations

No related citations found.