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Original Research
Cardioprotective effects and antioxidant status of Andrographis paniculata in isoproterenol-induced myocardial infarction in rats
Submitted: 13 December 2017 | Published: 31 January 2019
About the author(s)
Bisi O. Adeoye, Department of Veterinary Pharmacology and Toxicology, University of Ibadan, NigeriaTemitayo O. Ajibade, Department of Veterinary Physiology and Biochemistry, University of Ibadan, Nigeria
Ademola A. Oyagbemi, Department of Veterinary Physiology and Biochemistry, University of Ibadan, Nigeria
Temidayo O. Omobowale, Department of Veterinary Medicine, University of Ibadan, Nigeria
Momoh A. Yakubu, Department of Environmental Sciences, College of Science, Technology and Engineering, Texas Southern University, United States
Aduragbenro D. Adedapo, Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria
Abiodun E. Ayodele, Department of Botany, University of Ibadan, Nigeria
Adeolu A. Adedapo, Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria
Abstract
Background: Myocardial infarction has been regarded as one of the fastest killer diseases of modern-day man.
Aim: The protective effect of Andrographis paniculata on isoproterenol (ISO)-induced myocardial infarction in rats was investigated.
Setting: The study was carried out in a laboratory setting.
Methods: Animals were randomly divided into six groups of seven animals per group, and the treatment was as follows: normal control received normal saline for 9 days, isoproterenol group; three extract-treated groups in pre-treatment phase and an extract-treated group in post-treatment phase. The doses were given at 100, 200 and 400 mg/kg body weight for pre-treatment phase respectively while 200 mg/kg dose was given to the post-treatment phase group. Blood and heart tissues were collected for biochemical assays, haematological and histological analyses.
Results: Myocardial infarction was recorded in ISO group but was corrected by the extracts in both pre-treatment and post-treatment phases. The ISO group experienced a significant decrease in antioxidant parameters, whereas the extract at all doses caused a significant increase in the activities of in these parameters. The extract caused a significant decrease in malondialdehyde content and hydrogen peroxide generation, whereas reverse was the case for the ISO group. Although no significant histopathological changes were recorded for the extract, the ISO group showed marked histopathological changes. ISO caused higher expressions of cardiac C-reactive protein (CRP) and CTnI and decreased the expressions of IL-10β; but this was the opposite for the extract.
Conclusion: The ethanol leaf extract of A. paniculata significantly exhibits cardioprotective effects.
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Crossref Citations
1. Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes
Paul-Mihai Boarescu, Ioana Boarescu, Ioana Corina Bocșan, Raluca Maria Pop, Dan Gheban, Adriana Elena Bulboacă, Cristina Nicula, Ruxandra-Mioara Râjnoveanu, Sorana D. Bolboacă
Molecules vol: 24 issue: 15 first page: 2802 year: 2019
doi: 10.3390/molecules24152802