Original Research

Saponin-rich extracts reverse obesity and offer protection against obesity-induced inflammation in high-fat diet mice

Oluwamodupe C. Ejelonu, Simeon O. Oluba, Bankole O. Awolokun, Olusola O. Elekofehinti, Isaac G. Adanlawo
Journal of Medicinal Plants for Economic Development | Vol 5, No 1 | a101 | DOI: https://doi.org/10.4102/jomped.v5i1.101 | © 2021 Oluwamodupe Cecilia Ejelonu | This work is licensed under CC Attribution 4.0
Submitted: 01 July 2020 | Published: 25 January 2021

About the author(s)

Oluwamodupe C. Ejelonu, Department of Chemical Sciences, Biochemistry Program, Faculty of Science, Olusegun Agagu University of Science and Technology, Okitipupa, Nigeria
Simeon O. Oluba, Department of Biochemistry, Faculty of Science, Adekunle Ajasin University, Akungba Akoko, Nigeria; and, Clinical Biochemistry Units, Department of Medical Laboratory Science, Inland Medical Hospital, Ikare Akoko, Nigeria
Bankole O. Awolokun, Department of Biochemistry, Faculty of Science, Adekunle Ajasin University, Akungba Akoko, Nigeria
Olusola O. Elekofehinti, Bioinformatics and Molecular Biology Units, Department of Biochemistry, Faculty of Science, Federal University of Technology, Akure, Nigeria
Isaac G. Adanlawo, Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria


Background: Obesity is a medical condition that occurs as a result of excess body fat which increases the risk of several metabolic disorders. Non-availability of efficient classical treatment for obesity has led to propose alternative treatment using plant material.

Aim: To investigated the effect of saponin-rich extract of Lindackeria dentata (SLD) on obesity and some specific genes involved in inflammation and insulin resistance in the high-fat diet (HFD) on mice.

Setting: The plant leaves were collected from farmland in Igede Ekiti, South-western Nigeria and authenticated at a herbarium unit of the Department of Plant Science and Biotechnology, Ekiti State University, Ado Ekiti, Nigeria.

Methods: Saponin-rich extracts from Lindackeria dentata leaves were extracted using standard procedures, HFD was given to some selected mice for 12 weeks whilst monitoring blood glucose and body weight (bw) of the mice. Obese mice were treated orally with SLD 25 mg/kg, 50 mg/kg, 100 mg/kg and 200 mg/kg bw for 3 weeks, sacrificed, organs were collected and some biochemical assays were performed. Expression of some genes and histopathological study of the pancreas were also carried out using a standard scientific protocol.

Results: Saponin-rich extract of Lindackeria dentata treatment significantly reduced (p < 0.05) bw and adipose fat deposit, and caused partial restoration of pancreatic islet expansion (100 mg/kg and 200 mg/kg) coupled with accentuated regulation of leptin, insulin and IL-10 gene (25 mg/kg, 50 mg/kg and 100 mg/kg) when compared with control groups.

Conclusion: The present data clearly showed that SLD could be a good intervention in the treatment of obesity and its attendant metabolic disorders.


leptin; Lindackeria dentata; obesity; insulin resistance; anti-inflammatory; saponin


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